An investment property like a LTR or vacation rental? Well - if you buy another similar rental property within 180 days, then you pay no taxes. If you choose to (or can't) buy another property, then you pay a tax on the gain that you have made. It's a little complicated so I would contact a CPA, or at least look it up online to guessimate how much you might have to pay.
Now if this is your personal residence, it's all different....