Questions about mortgages with W2's and 1099

Hi all! 

I am planning to buy my first property in less than two years, and I know that to qualify for a mortgage, I must show tax returns from the past two years. I currently hold a 9-5 and a self-employed position. To qualify for a mortgage (and hypothetically speaking, of course!) is it possible to leave my W2 job, and still continue on my 1099 side gig? Please let me know your thoughts. Also, if anyone is in CA, where is a good place to begin investing?