Could renting by the room affect Appraisal, Refi & HELOC

I am considering renting a 3 br apartment by the room. This is in a 3 unit house where I will be living in one of the units and the 3rd unit is rented with a typical lease. Renting by the room makes sense for the location since if I listed the whole apartment I would likely get 3 friends wanting a roommate situation anyways. I would prefer to have an individual lease with each tenant in these cases. So my question is: I plan on doing a refi or getting a HELOC within the next year. Will the above affect the appraisal of the property? Do lenders frown upon this arrangement? Could this cause any issues with a refi or heloc application? Thanks in advance for taking the time to respond!