You can screen to your heart's content, and it will not make one bit of difference. I have some good families with Sec 8, and I've had some awful ones, too. But not a one of them would EVER have passed any stringent screening. These are not people with good credit scores. Sec 8 doesn't pay the deposit, but sometimes tenants have agencies that pay it for them - and tenants who are in the position of needing an agency to pay their deposit are virtually guaranteed to be trouble. The best you can get is a family that doesn't have a history of evictions, criminal convictions, or slip and fall lawsuits against landlords (you'd be surprised how very common these are), who is able to use their earned income tax credit for the deposit.
If you had a property that was in poor cosmetic condition already, that needed to be repainted, needed new flooring, needed new kitchens and bathrooms, already had a ruined lawn/driveway, and you planned to run it into the ground renting to Sec 8 for many years, then either renovate to sell, or sell it in "as is" condition, sure. By the time Sec 8 knocks down what they are willing to pay, by deducting all the utilities that you're not providing, and calculating "rent reasonableness" for the unit and the area, it might be a little more than you would get on the open market. But if it's in decent condition, understand that the tenants WILL destroy it. They will smoke in it even if they swear they don't. They will bring in pets who will at best soil the carpets and floors and destroy the yard, and at worst bite or maul neighbors. Their children will absolutely tear the house apart. The little children will swing on the lower cabinet doors, breaking them off. They will jump on the open oven door, breaking it off. They will tear every "kick plate" off of every appliance. They will break the handle of the refrigerator off, by swinging on it. They will break the toilet seat off the toilet - God only knows how they do that one. They will break the latches and knobs/handles off of the doors, punch holes in the walls and doors, bust latch plates out of the door frames. They will burn the carpets with irons, put deep, deep scratches into any hard floors. If you are foolish enough to include utilities, they will run heat and a/c with the windows and doors open, heat it to 80 degrees in the winter and cool it to 65 in the summer. If they can have a washer/dryer, they will bring in the entire clan's laundry, and charge their friends to to do laundry there - the machines will run 24/7 nonstop. And these are the GOOD ones! The ones who pay their portion of the rent, sign their paperwork with the housing authority, allow you access to make the copious repairs that the housing inspector will require annually, don't deal drugs, don't threaten and menace their neighbors and you. The bad ones will deal drugs, prostitute their children, rent out rooms to extra tenants, terrorize the neighbors and you, and drag their feet about returning their portion of the annual renewal paperwork to the point that the housing authority stops paying you - even though their tenants still live there!
If this sounds like a description of a cage, rather than a dwelling, understand that that is how they will use it. Yes, there are some exceptions. But when you're talking about a large family on Sec 8, the odds are very high that this is what you will get in there, no matter how good they looked on screening.
But hey, don't listen to the vast majority of landlords of grade A/B and even C housing who would never, ever rent to Sec 8. And don't listen to LLs like me who do rent C housing to Sec 8 at times for over a decade now. What do we know?