Buying "A class" neighborhood in a "C class city"- your thoughts?

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 Location, Location, Location they say. I have recently run across some investment opportunities to invest in the "A class" neighborhood but the city itself is "C class"  

Positives- Highest quality tenants, 10-20% higher rents, 25-30% higher property values, Better school district

Negatives- Loss of potential renters due to higher rents, Hard re-sell due to highest prices in the city

Any advice on these type of opportunities that I should consider would be greatly appreciated.