Worried about debt to income ratio

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I'm working my way toward a 20% down payment for a conventional loan on my first investment property (buy & hold rental, single family home). My credit score is high and my reserve funds are adequate, but my mind is stuck on my debt to income ratio. The only debt I have is a low-to-no balance credit card and personal residential mortgage. But that mortgage is creating a high DTI ratio. Is that sometimes overlooked by lenders if other factors outweigh the high ratio?