Tax advantages of STR and Primary Residence

[Aman Kataria]

I just bought a new home as a primary residence. I use 2/3 of the home for short term rental on Airbnb. 

Am I allowed to make tax deductions on both - 1) Mortgage Interest, and 2) Offset my passive income with STR (only on the 2/3 of the property)?

I manage my own rentals and should be able to meet the material participation clause.

Appreciate any advice.