A deal is a deal
Just be aware that you will probably have a different set of buyers many wholesale buyers of SFR are flippers, where almost none of the wholesale buyers for plexes will be flippers.
@Malik Batchelor I think the biggest thing would be to ensure that you are offering a good deal. That being said many buy and hold investors will want to see deals that works with their BRRR strategy. After purchase and rehab they would like to be at or under 80% LTV so they can refinance and get their cash back to roll into another deal. I hope that helps.